产品货号：
Z34618
中文名称：
Ms CD5 Purified抗体
英文名称：
Anti-Ms CD5 Purified Antibody (Clone#53-7.3)
产品规格：
0.1mg(C100)
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Ms CD5 Purified Antibody (Clone#53-7.3) |
| 指标别名 | CD5;CD5 molecule;LEU1;Lymphocyte antigen T1/Leu 1;T1 |
| 克隆性 | Monoclonal |
| 检验物种 | mouse |
| 应用范围 | FCM,IP,IHC,IHC-F |
| 基因名称 | CD5 |
| 克隆号 | 53-7.3 |
| 抗体来源 | Rat |
| 免疫原 | Murine thymus or spleen cells.The rat monoclonal antibody 53-7.3 recognizes an extracellular epitope of CD5,a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes,most of thymocytes and B-1 lymphocytes. |
| 计算分子量 | 54kDa |
| 成分 | Phosphate buffered saline (PBS),pH7.4,15mM sodium azide |
| 纯化方式 | Purified by protein-G affinity chromatography. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Store at 2～8℃.Do not freeze. |
| 背景资料 | CD5 antigen (T1;67kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein.CD5 is expressed on all mature T-lymphocytes,most of thymocytes,subset of B-lymphocytes and on many T-cell leukemias and lymphomas.It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains.The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity.CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR).CD5 crosslinking induces extracellular Ca++ mobilization,tyrosine phosphorylation of intracellular proteins and DAG production.Preliminary evidence shows protein associations with ZAP-70,p56lck,p59fyn,PC-PLC,etc.CD5 may serve as a dual receptor,giving either stimulatory or inhibitory signals depending both on the cell type and development stage.In thymocytes and B1a cells it seems to provide inhibitory signals,in peripheral mature T lymhocytes it acts as a costimulatory signal receptor.CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.Disease relevance:CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL,Hairy cell leukemia,etc.).The CD5+ popuation is expanded in some autoimmune disorders (rheumatoid arthritis,etc.).Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells. |
| Uniprot ID | P13379 |
| 基因名全称 | CD5 molecule |
| 蛋白名全称 | T-cell surface glycoprotein CD5 |
| 推荐稀释比 | Flow cytometry:1～4μg/mL. |
相关搜索：Ms CD5 Purified抗体，Ms CD5 Purified单抗，Anti-Ms CD5 Purified Antibody (Clone#53-7.3)